The SSRI, referred to as the selective serotonin reuptake inhibitors are drugs used as antidepressants and anxiolytics mainly to treat major depressive disorders and anxiety disorders respectively.
The SSRI are usually prescribed as first choice medications for the treatment of persistent or severe cases of depression and are sometimes used in combination with the Cognitive Behavioral Therapy; CBT (talking anti-anxiety medication and/or antidepressant therapy that can help a subject manage his or her problems by improving the subject’s mood, behaviors and gestures.
Apart from the antidepressant/anti-anxiety effects of the SSRIs, they can also be used to treat other mental conditions such as generalized anxiety disorder (GAD), obsessive compulsive disorder (OCD), panic disorder, severe phobias (agoraphobia, social phobia), bulimia and post traumatic stress disorder (PTSD).
Furthermore, SSRIs are indicated in premature ejaculation, premenstrual syndrome (PMS), fibromyalgia and in irritable bowel syndrome (IBS).
The mechanism of action of these groups of drugs is by raising the level of a neurotransmitter; “serotonin” in the brain.
SSRIs are known to increase the extracellular levels of serotonin by inhibiting its reuptake into the pre-synaptic cell. By doing so, the level of serotonin present in the synaptic cleft to bind to the post-synaptic receptor will be increased.
The above mechanism means that more serotonin will be available to pass messages between the nerve cells. The ability to increase the serotonin levels in the nerve cells is what gave rise to the SSRI antidepressant effect, hence the drug class; anti-anxiety medication.
The SSRIs are known to have good influence on ones mood, sleep and emotion.
Some people would experience side effects while on SSRI drugs. These may include dizziness, blurred vision, low sex drive, erectile dysfunction, prolonged orgasm, malaise and anxiety.
Wellbutrin is the most frequently prescribed antidepressant drugs in the United States. The active pharmaceutical ingredient in wellbutrin is bupropion hydrochloride; also referred to as amfebutamone.
Wellbutrin is usually prescribed for the treatment of major depressive disorders and seasonal affective disorders. That is, it is an antidepressant drug.
The very common side effects of wellbutrin are insomnia and headache. Other wellbutrin side effects are fever, asthenia, dizziness, agitation, anxiety, alopecia, tremor, concentration disturbances, dry mouth, nausea, vomiting, constipation, rash, abdominal pains, pruritus, sweating, urticaria, taste disorders, depression, visual disturbances.
The rarely experienced side effects of wellbutrin includes syncope, orthostatic hypotension, vasodilatation, hypotention, palpitation, hallucinations, irritability, hostility, seizures, depersonalization, parkinsonism, dystonia, ataxia, twitching, abnormal dreams, memory impairment, parasthesia, delusions, paranoid ideation, aggression, restlessness, blood glucose disturbances, arthralgia, myalgia, erythema multiforme, Steven Johnson syndrome, urinary retention, elevated liver enzymes, jaundice, hepatitis, malaise, angioedema, dyspnoea, bronchospasm and anaphylactic shock.
Epileptic seizure is the most common adverse effect of wellbutrin and this lead to the temporary withdrawal of the drug from the market between the year 1986 and 1989.
Commonly used antidepressant list of drugs includes Prozac, Celexa, Luvox, Zoloft, Paxil, Lexapro, Viibryd, Brintellix with Zoloft, Paxil and Prozac being the most commonly used antidepressants in the anti-anxiety medication lists.
The SSRIs are very important classes of drugs which have several therapeutic benefits on subject for which they are used.