Metformin has brand names Glucophage, Fortamet, Riomet. It is an oral anti-diabetic medicine meant specifically for Type 2 Diabetics (for diabetics who do not need to take a daily injection of insulin). Metformin has become the most commonly prescribed oral medication for the treatment of diabetes. Metformin helps reduce plasma glucose levels and lowers the production of glucose by the liver, without increasing the concentration of insulin in the blood’ This unique effect on blood insulin level is what separates Metformin from other glucose-lowering drugs of the sulfonylurea class, e.g. glyburide (Micronase; Diabeta) or glipizide (Glucotrol). It does this by increasing the sensitivity of muscle and fat cells to the absorption of insulin, thus improving glucose uptake from the bloodstream. Insulin metabolizes glucose, but if cells are not sensitized to insulin, both insulin and glucose will stay in the blood stream and not get transported to body cells.
Scientific studies had been conducted to prove that Metformin reduces the complications of diabetes such as heart and kidney diseases, as well as blindness. Metformin has been approved by the FDA since 1994. It has been successful in lowering blood sugar levels without going about it excessively. If blood glucose level is overly reduced, this will lead to hypoglycemia with common symptoms ranging from headache, mild confusion, dizziness, sweating, and abnormal behavior, to loss of consciousness, seizure, and coma.
METFORMIN SIDE EFFECTS
Metformin side effects can sometimes look similar to those found in hypoglycemia. One must get emergency medical help if any of such symptoms of lactic acidosis; weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting are found. This condition of lactic acidosis is likely to develop if one has congestive heart failure, impaired kidney, or liver functions. ln addition, older individuals are more susceptible to contracting it. The most common ones occur when the drug affects normal digestion such as diarrhea, nausea, indigestion and abdominal discomfort. Weakness and headaches are reported in clinical trial as well. Also Metformin makes it more difficult to absorb vitamin Bj.2, sometimes resulting in long-term users requiring a vitamin 812 supplement.
Hypoglycemia is not likely to occur just by using Metformin. However, low blood sugar is possible if Metformin is used in combination with other anti-diabetic medications. Some common symptoms of hypoglycemia include unusual appetite, lethargy, dizziness, shaking and sweating, and loss of consciousness. It is possible to have an allergic reaction to Metformin, although, this isn’t common as it is best to be cautious and look out for any unusual signs. These could actually be allergy symptoms. Common allergic symptoms include skin irritation, chills, dizziness, respiratory problems, swelling, and unusual drowsiness.
A popular aftermath of metformin consumption is the occurrence of nausea. Introduction of a medicinal agent in the body sometimes interfere with the customary regulation of hormonal flow. Such a mode of discomfort originating in the abdominal lining of the stomach leads to nausea, cramps, diarrhea, infections like rotavirus and even vomiting.
Lactic Acidosis is a serious condition when there is too much Lactic Acid in the blood and requires immediate medical attention. Doctors are very careful in screening out patients who are prone to the disease, and when used properly, Metformin by itself is low risk for developing Lactic Acidosis. For those who have liver and kidney problems, there is the possibility of Metformin building up and not filtering out of the body properly. Since Glucophage is introduced in the body to terminate the detrimental effects of the disorder of diabetes mellitus, abnormalities might foster the production of glucose in a rapid pace compared to the procedure of metabolization. This generates an aching sensation in the muscles and joints with accessorizing offshoots of turbulent breathing, abdominal pain and vomiting accompanying it.
Polycystic Ovary Syndrome
Metformin side effects in women include the prevalent disorder of PCOS. Some of the grotesque symptoms are irregular phases of menstrual periods, fertility complications, disrupted hormonal activities and even damaging cardiac conditions. The drug restricts the scope of fertilization in females and bars the process of ovulation, thereby leading to the formation of ovarian cysts, depression, anxiety, vexatious ache in the pelvic region, apnea and a considerable gain in the body weight. To enhance the conceiving capacity of the female, drugs like Clomiphine citrate is suggested.
The frequent diminishing status of water component from the body paves way for the occurrence of dehydration. A human body experiences dynamic fluctuations and fails to monitor the amount of water content required to perform the customary metabolic activities.
The impact of metformin extends to the occurrence of the disorder of hypoglycemia or reduced level of sugar in the blood stream. It is noticeable with the symptoms of headache, discomfort generating dizziness, enhanced velocity of pulse rate and fainting.
One of the PoPular condition of hyperglycemia. This results in an further creates afflictive reaction.
Other side effects might include symptoms of an allergic reaction such as throat, tongue, lip, or face swelling, breathing problems, or hives. One might also experience shortness of breath, even with the mildest of exertion, rapid weight gain, swelling, flu-like symptoms, body aches, chills, fever, headache, weakness, or even mild nausea. While taking Metformin, you might experience stomach pain, gas, diarrhea, vomiting, or muscle pain as well. If one has a history of heart, liver of kidney disease, do not take metformin. If one is in a state of diabetic ketoacidosis (over production of glucose from the breakdown of the body muscle and fat tissues), call the doctor for treatment with insulin.
Patients with diabetes are thought to be at increased risk of developing certain types of cancer, as well as being at an increased risk of developing a recurrence of previously diagnosed cancers. The minor side effects are usually temporary as the body attempts to adjust to the medication. Metformin side effects could last for several weeks, but many report that they experience discomfort for only days instead. There is the possibility of more long-term side effects, which may require consulting the doctor who may recommend a lower dose. Whether or not side effects occur depends on which brand of Metformin, and how an individual body will respond to it. Most report less severe side effects when taking a long-acting form of Metformin. Many brands have an ER (extended release) form that usually only requires one dose per day’ However, some side effects still occur often enough to mention such as diarrhea, and nausea or vomiting. It should be noted that if one is experiencing distress due to the medication, it’s not recommended that one alters the dosage oneself but instead notify the doctor. There are many brands available that one’s doctor may prescribe as an alternative, but unfortunately, a few people just cannot tolerate any kind of Metformin. Most doctors believe that Metformin itself doesn’t adversely affect the liver and kidneys unless the patient has a precondition. People younger than 17 years old should not take slow release Metformin. In any case, no children below 10 should be given any form of it.
METFORMIN WEIGHT LOSS
Metformin has active ingredient which are isolated and identified. This compound belongs to a group of drugs called the biguanides. Metformin consists of two linked guanidine rings. Even though it has been used to treat diabetes for more than 3 decades the exact mechanisms of action remain more or less is a mystery and it is only recently that the scientists have been able to diagnose the same. Metformin has a number of different effects on glucose metabolism. As a result of this there is improved insulin sensitivity in tissues like muscles and liver. Advantages of Metformin also include decrease in gluconeogenesis or the synthesis of glucose from non-carbohydrate sources by the liver. The overall effect of Metformin helps to decrease glucose levels. But since Metformin is a euglycaemic agent, blood glucose levels don’t fall below normal and hence hypoglycaemic episodes do not occur. It also has various benefits on lipid metabolism and hence the lowering of circulating fatty acids occurs. It also helps to reduce VLDL which is also involved in causing cardiovascular disease like circulation of fatty acids.
There are various reasons for being overweight one of them is insulin. This form of fat is stored primarily in your belly. As the person eats, the blood sugar level rises. The more the level rises, the more insulin is released in the pancreas. Insulin can make one fat by acting on the brain to stimulate signs of hunger. This leads to the liver manufacturing fat and the fat cells in the belly to fill with fat. The best way to treat this form of obesity is to avoid foods that cause the highest rise in blood sugar. Taking medications that prevent rise of blood sugar levels from is also suggested. All forms of bakery products, pastas, and foods made from flour, fruit juices and products with added sugar should be avoided. Fruits and root vegetables such as potatoes should be consumed only with meals. The sugar eaten by the body comes to intestines through the bloodstream, and into the liver.
Metformin contains glucophage which reduces sugar release from the liver to reach the blood sugar levels and raise them too high. Hence the body doesn’t need to produce as much insulin that makes one hungry. Hence the liver does not convert sugar to fat. There are various other benefits of Metformin apart from curing diabetes and it is losing weight. But Metformin is not effective when blood is acidic due to excess lactic acid.
Metformin helps in lowering insulin levels which are very helpful in curing diabetes. Metformin is also an effective treatment for different kinds of diabetes. Since it acts at the source of the problem it helps to fight insulin resistance and also prevents and delays the onset of type 2 diabetes which leads to impaired glucose tolerance and insulin resistance. It also helps to reduce risk of diabetes-related death, heart attacks and strokes various other diseases.
Metformin weight loss is basically used by the people who are suffering from diabetes. This drug is used for treatment by people who have diabetes and it also helps them in reduction of their weight as well. However, just using Metformin in usual routine for control of diabetes may not result in reduction of weight. It helps in weight loss if properly used in a prescribed way.
It is advisable not to go for Metformin weight loss oneself without consulting a doctor, as it contains a drug as its component. Using this drug without consulting the doctor may cause damage to one’s health. As everyone has his own individuality and it depends on person to person, which drug suits and which does not. For a diabetic person, Metformin weight loss is quite easy. It may be used to control the diabetes, so it will be easy for one to make just little changes in the daily routine to get the benefit of losing weight with the help of this medicine. It has dual capabilities; it can control diabetes and can also reduce weight sometimes. A little change in diet can give one positive results within weeks.
People who consume low carbohydrates, usually get effective results from Metformin as compared to people who consume a high amount of carbohydrates in their meal. But people who have diabetes or who are pre diabetic, this factor of consuming too many carbohydrates does not fail the concept of Metformin weight loss for them. Exercise is must for effective results. Light or moderate exercises for almost 30 minutes will be enough to reduce weight. It has been noticed that affectivity of Metformin weight loss is more if used with a combination of exercises. Metformin actually functions in such a way that it lowers the level of glucose and then increases the sensitivity of insulin.
Metformin hydrochloride (HCL) is a drug that is prescribed by doctors to patients who are experiencing type 2 diabetes. It is a good method for children, age ten and older, and adults to try if they are dealing with the condition. When Metformin HCL is used in combination with a good diet and excellent exercise habits there is no way that positive results will not occur. What it does for patients that have type 2 diabetes is make sure that blood sugar stays under control. The drug is able to do this by decreasing the amount of sugar that the liver generates, decreasing the amount of sugars that gets absorbed by the body and by helping the body be able to respond to its own insulin better. Even though this drug is primarily for diabetes type 2 patients there have also been some reports of it working for other conditions as well, such as, gestational diabetes, polycystic ovarian syndrome and HIV lipodystropy.
When one first starts off taking Metformin hcl the doctor will probably start them off with a dosage of 500 mg twice a day. For children who are between the ages of ten and sixteen they will be allowed to take no more than 2550 mg and for adults they will be allowed to take no more than 2550 mg. However, the doctor will let one know when, and if, the dosage needs to be increased. Usually, the dosage will be increased gradually so it will be less likely that side effects will occur. It can be taken with insulin, however the doctor may give different dosage instructions to make sure that no bad things occur.
Just like with any other prescription it is possible to overdose on Metformin hydrochloride. If one happens to overdose on Metformin hcl, one may experience low blood sugar and/or lactic acidosis. One will know if one has low blood sugar as one will experience some of the following symptoms; blurred vision, shakiness and an extreme feeling of hunger. Also, one will know if one is experiencing lactic acidosis because one will experience some of the following symptoms; irregular heartbeat, shortness of breath and extreme hunger.