NSAIDs or non-steroidal anti-inflammatory drugs are medicines with analgesic and antipyretic effects. These drugs are usually composed with higher doses and are known for its anti-inflammatory effects. Non-steroidal significantly emphasizes what NSAIDs’ general composition and these drugs do not contain steroids. They are a class of drugs, some prescribed by doctors and others available over the counter, for the treatment of inflammation, mild to moderate pains, arthritis and fevers. NSAID’s work in conjunction with the body’s coenzymes, Coxl and Cox2. Those coenzymes are responsible for releasing prostaglandins, which, in turn, cause pain, inflammation and fever. By taking NSAID’s, one can inhibit this reaction, thus reducing the production of prostaglandins and the pains one might be experiencing.
Unfortunately, by preventing the prostaglandins from causing fever and pain, one is likewise preventing the coenzyme Coxl from performing an extremely vital function such as protecting the stomach. Prostaglandins produced by Coxl are responsible for protecting the mucous lining of the stomach, as well as supporting the body production of platelets, a blood component instrumental in the blood’s ability to clot. By taking a large amount of NSAID’s over an extended period of time, there is the risk for damage to one’s stomach lining, an ulcer, or uncontrolled bleeding. NSAID also have other general stomach-related side effects one needs to be wary of, such as decreased appetite, constipation, diarrhea, vomiting and nausea.
Some existing conditions and issues that may interfere with someone’s ability to use NSAIDs.
- Liver Disease: NSAIDs are processed by the liver, so anyone with reduced liver function shouldn’t take NSAlDs.
- Excessive Bleeding – It doesn’t matter if a person has an increased risk of bleeding due to a medical condition or due to a blood thinning medication (such as warfarin), it’s unsafe to use NSAIDs. A common side effect of these drugs is that they prevent clotting and thin the blood. This is the effect that makes aspirin an effective preventative medicine in low doses. Combined with other blood-thinning factors, though, the use of NSAIDs could be dangerous.
- Allergies: If someone is allergic to one NSAID, it’s very likely that person will be allergic to all of them. Allergies can be relatively mild – a rash, some tingling of the lips or tongue, or even something as simple as itching. Severe reactions might be hives, asthma attacks, or severe swelling of the lips, tongue, or throat.
- Kidney Problems – Another common side effect of NSAIDs is reduced kidney function. So anyone taking these medications need to be aware that they reduce the effects of diuretic drugs. And since the kidneys are also responsible for removing certain materials from the bloodstream, NSAIDs prevent the body from getting rid of the drugs lithium and methotrexate.
- Pre-Existing Heart Condition: With the exception of low-dose aspirin, NSAIDs have a well-known side effect of causing heart problems. They can cause high blood pressure, heart attack, and stroke. These effects are dose dependent, and are especially common in people taking NSAIDs as a long-term option.
- Pregnancy – NSAIDs aren’t safe to take during pregnancy, especially the third trimester. Many of these drugs are used as a treatment for a condition called patent ductus arthrosis, a condition found in newborns in which a special blood vessel doesn’t close after birth like it should. Should that blood vesselclose too soon, it could result in serious complications, so NSAIDs aren’t good for pregnant women.
- Children and Babies – In general, these medications are not for young people’ They can cause serious illnesses in children if over-used. Likewise, it’s not safe for nursing mothers to take NSAIDs as they can pass from the mother to child through the milk.
- Regular Drinking – Drinking alcohol with NSAIDs significantly increases the risk of many side effects, especially stomach and intestinal bleeding. The two drugs should never be consumed together, and anyone who regularly has more than 3 drinks a day should not use NSAIDs regularly.
IS TYLENOL AN NSAID?
No, Tylenol (acetaminophen) is not classified as an NSAID (nonsteroidal anti-inflammatory drug). Tylenol is classified as a miscellaneous analgesic for mild to moderate pain and fever. It is hypothesized that acetaminophen may inhibit COX enzymes, similar to the way NSAIDs work, but without the anti-inflammatory component. Tylenol typical has a lower effect on inflammatory pain than NSAlDs. Acetaminophen may act by several different mechanisms, but the exact mechanisms have still not been defined. Acetaminophen is used to treat many conditions such as headache, arthritis, muscle aches, backache, toothaches, colds, and fevers. Acetaminophen is usually the pain reliever of choice for patients who take a blood thinner. Acetaminophen does not inhibit thromboxane and does not alter platelet aggregation, like aspirin.
However, if one takes a blood thinner, be sure to check with the doctor or pharmacist before taking acetaminophen as prolonged or high doses of acetaminophen may lead to bleeding. If one combines a blood thinner with acetaminophen, be sure to report any signs of bleeding to the doctor, including pain, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, gum bleeding, unusual bruising, red or brown urine, or red or black stools.
Major Side Effects
If any of the following side effects occur while taking acetaminophen, check with your doctor immediately:
- Bloody or black, tarry stools
- bloody or cloudy urine
- fever with or without chills (not present before treatment and not caused by the condition being treated)
- pain in the lower back and/or side (severe and/or sharp)
- pinpoint red spots on the skin
- skin rash, hives, or itching
- sore throat (not present before treatment and not caused by the condition being treated)
- sores, ulcers, or white spots on the lips or in the mouth
- sudden decrease in the amount of urine
- unusual bleeding or bruising
- unusual tiredness or weakness
- yellow eyes or skin
If any of the following symptoms of overdose occur while taking acetaminophen, get emergency help immediately:
Symptoms of overdose:
- increased sweating
- loss of appetite
- nausea or vomiting
- stomach cramps or pain
- swelling, pain, or tenderness in the upper abdomen or stomach area
Non-steroidal anti-inflammatory drug or NSAIDs list is one registry of drugs one should get familiarize with. As NSAIDs are the most common over-the -counter drugs, it is just necessary that everyone should take chance of obtaining a copy of NSAIDs list. Having the Non-steroidal anti-inflammatory drug list will enable people to determine the appropriate medicine that they should take when they have acquired fever or some bodily pains.
The leading drugs in the NSAIDs list are those that highly common and can be purchased by anyone in almost all pharmacies or drugstores. Aspirin, ibuprofen, and naproxen, are those leading drugs that are available in all pharmacies worldwide. Below are the common NSAIDs:
- Celebrex – an anti-inflammatory allergy medication. Available by prescription only. Proven to be relatively safe for the stomach, with a limited number of negative side effects.
- Ketorolac – a rather potent NSAID that functions as a pain blocker. Excessive usage can cause extreme damage to the lining of your stomach.
- Advil – available over the counter and generally taken as a mild pain blocker. Excessive usage puts one at risk for ulcers and uncontrollable bleeding. Due to its ability to prevent blood from clotting for an extended period of time (4-7 days), it is often prescribed by doctor for patients at risk for heart attacks and stroke.
- Etodolac, Tolmetin, Oxaprozin, Sulindac, Indomethacin – prescribed by doctors for the treatment of mild pains, cramps, fever and inflammation suffered by those with rheumatoid arthritis and osteoarthritis.
- Ibuprofen, Naproxen – available over the counter for the treatment of mild pains, cramps, fever, and inflammation.
Others are Aspirin, Fenoprofen calcium, Ketoprofen, Meloxicam, Diclofenac sodium, Valdecoxib, Diclofenac potassium, Celecoxib, Tolmetin sodium, Diflunisal, Magnesium salicylate, Salsalate, Meclofenamate sodium, Flurbiprofen, Mefenamic acid, Choline saticylate, Naproxen sodium, Diclofenac sodium with misoprostol, Choline and magnesium salicylates, Sulindac, Oxaprozin, Piroxicam, Rofecoxib, Sodium salicylate, Nabumetone.
NSAIDs list of drugs have had helped many individuals worldwide in surviving pains and inflammations. The presence of these drugs enables various patients to administer personally their medical needs. However, individuals should evaluate or observe their conditions if NSAIDs are the appropriate solution for their condition. For recurring pain or inflammation, patients should take chance to consult their local health professionals in order to know the appropriate medicine that should be taken. For those who are enduring pain and inflammation and have no time visiting their doctors, such should give time in knowing what NSAIDs’ various benefits are and what kind of drugs in the NSAIDs list that is appropriate in that condition.
NSAIDs inhibit the production of platelets, which enable blood to clot, it is dangerous to take NSAID’s if one is already on another medicine that affects blood clotting ability. NSAIDs have also been proven to raise blood pressure in people with hypertension, and therefore they are not recommended for use by such people.